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Association between Guillain-Barré syndrome and Herpes virus family members, A Multiplex PCR study

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1Awatef M. Awwad, 2Ghada A. Ashmawi, 1Yasmin E. Hassan, 1Sara L. Asser*
1Microbiology and Immunology Department, Faculty of Medicine, Alexandria University
2Neuropsychiatry Department, Faculty of Medicine, Alexandria University


Background: Guillain-Barré syndrome is a serious autoimmune peripheral neuropathy, in which the immune system attacks healthy nerve cells. The reason for this condition is unknown; however it is usually triggered by an associated infection, gastrointestinal or a respiratory, and to a less extent vaccination. Several infections have been encountered preceding Guillain-Barré syndrome: Campylobacter jejuni, Influenza, Cytomegalovirus, Epstein-Barr virus, Mycoplasma pneumonia and HIV. Objectives: The aim of this research is to evaluate the etiological correlation between CMV, EBV & HHV-6 infection and Guillain Barre syndrome. Methodology: Peripheral blood samples were collected from 30 patients attending the clinic of Neurology Department, as well as 20 control subjects, to identify the presence of the CMV, EBV & HHV-6 viral genome by Real-time multiplex RCR. Results and Conclusion: This study revealed that CMV UL 32 gene was significantly higher among studied cases as compared to controls and thus may be an attributable etiological agent for triggering the disease.

About EJMM

The Egyptian Journal of Medical Microbiology EJMM  ISSN Print 1110-2179 - ISSN Online: 1110-2179, The official publication of Egyptian Society of Medical Microbiology

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