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Immunological Modulation of HAV and HEV Positive Children

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1Omnia G. Megahed, 2Ahmed S. Ahmed, 2Michael N. Agban, 2Amany M. Adawi,
3Naglaa H. Ibrahim, 4Mohamed M. Amin*
1Children’s Hospital, Assiut University
2Department of Microbiology and Immunology, Faculty of Medicine, Assiut University
3Department of Pediatrics, Faculty of Medicine, Assiut University
4Department of Microbiology and Immunology, Faculty of Medicine, Aswan University

ABSTRACT

Background: hepatitis E virus (HEV) and hepatitis A virus (HAV) are acute hepatitis that infects mainly children. They are feco-orally transmitted disease. Objectives: detection of the prevalence of HAV and HEV in children with acute hepatitis and their correlation with the immune response. Methodology: 151 hepatic children from Children’s Hospital in Assiut were enrolled in our study. Anti-HEV IgM, anti-HAV IgM, liver function tests and the immune response using Flow Cytometry measuring CD4+CD25+Foxp3 and intracellular IL-10 were measured. Results: in anti HAV-IgM patients, 66.36 % were males and 33.64 % were females, 42.72 % were urban and 57.28 % were rural, while in HEV-IgM positive patients 57.14 % were males and 42.86 % were females. 42.86 % were urban and 57.14 % were rural, the level of CD4+CD25+Foxp3 was statistically significant (P=0.027), and IL-10 was statistically significant (P=0.007). Conclusion: there was a significant correlation between the presence of the viruses and the immune response.

About EJMM

The Egyptian Journal of Medical Microbiology EJMM  ISSN Print 1110-2179 - ISSN Online: 1110-2179, The official publication of Egyptian Society of Medical Microbiology

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